Institute BCN® Argireline

ANTI-WRINKLE SOLUTION

Inspired by the Mesobotox treatment, this solution combines two ingredients to achieve a mild, non-toxic Botox effect. It reduces and prevents emotional wrinkles by inhibiting muscle contraction.

Faces with more complex expressions and whose overlapping of muscular functioning are a standard contra-indication of the Botox, since this would lead to rather sinking and the general aspect becomes sad. Argireline, acetyl hexapeptide-3 a unique peptide, is a chain of six amino acids that both reduces the degree of existing facial wrinkles and has been demonstrated effective against their development. This solution is a non-toxic, safer and milder alternative to Botulinum Toxin, topically targeting the same wrinkle-formation mechanism in a very different way.

Muscular contraction is attenuated twice by blocking ions entrance with leuphasyl, and modulating the formation of the SNARE complex with argireline. Muscles are contracted when they receive neurotransmitter released from a nerve cell and Botulinum Toxin A paralyses the muscle by selectively blocking acetylcholine release at the neuromuscular junction. BONT-A cleaves the protein SNAP-25 irreversibly, and therefore the SNARE complex cannot assemble. Argireline is a mimic of the N-terminal end of SNAP-25 and it competes with the natural protein for a position in the SNARE complex, so it destabilizes its formation, without breaking any of its components. If the SNARE complex is slightly destabilized, the vesicle cannot release neurotransmitters.

Leuphasyl, a pentapeptide mimics the natural path of enkephalins, acting on expression wrinkles formation in a new way. It is a modified enkephalin that couples to the enkephalin receptor, outside of nerve cells.